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Levering av kardioaktive terapier i en myokardinfarktmodell hos svin
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Levering av kardioaktive terapier i en myokardinfarktmodell hos svin

Article DOI: 10.3791/64177-v • 07:20 min • February 10th, 2023
February 10th, 2023 •
*1,2, *1, 1,2, 1, 2, 2, 2, 2, 3, 4, 2, 2, 1,2, 1,2
1Centre for Heart Research, The Westmead Institute for Medical Research, The University of Sydney, 2Department of Cardiology, Westmead Hospital, 3Sydney Imaging, Core Research Facility, The University of Sydney, 4Department of Cardiothoracic Surgery, Liverpool Hospital
* These authors contributed equally

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Denne protokollen beskriver tre metoder for administrering av kardioaktive terapeutiske midler i en svinemodell. Kvinnelig landrasesvin fikk behandling gjennom enten: (1) torakotomi og transepikardial injeksjon, (2) kateterbasert transendokardial injeksjon, eller (3) intravenøs infusjon via halsvene osmotisk minipumpe.

Tags

Kardioaktiv terapi hjerteinfarkt legemiddellevering svinemodell store dyremodeller terapeutisk administrasjon svin preklinisk evaluering nye midler torakotomi transepikardial injeksjon kateterbasert transendokardial injeksjon intravenøs infusjon osmotisk minipumpe i jugularven reproduserbare prosedyrer pålitelig legemiddellevering translasjonsvitenskap
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