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Journal / Bioengineering / Kardiotoksicitetsscreening med høj kapacitet ved…
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Bioengineering

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JoVE Journal Bioengineering
Kardiotoksicitetsscreening med høj kapacitet ved hjælp af modne humane inducerede pluripotente stamcelleafledte kardiomyocytmonolag
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Kardiotoksicitetsscreening med høj kapacitet ved hjælp af modne humane inducerede pluripotente stamcelleafledte kardiomyocytmonolag

Article DOI: 10.3791/64364-v • 14:03 min • March 24th, 2023
March 24th, 2023 •
1, 2, 3, 1, 1
1Frankel Cardiovascular Regeneration Core Laboratory, Cardiovascular Medicine-Internal Medicine, University of Michigan, Ann Arbor, 2CAIRN Research, 3StemBioSys, Inc.

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Human induceret pluripotent stamcelleafledte kardiomyocytter (hiPSC-CM'er) tilbyder et alternativ til at bruge dyr til præklinisk kardiotoksicitetsscreening. En begrænsning for den udbredte anvendelse af hiPSC-CM'er i præklinisk toksicitetsscreening er cellernes umodne, føtallignende fænotype. Her præsenteres protokoller for robust og hurtig modning af hiPSC-CM'er.

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Denne måned i JoVE nummer 193
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