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JoVE Journal
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JoVE Journal Medicine

심정지, 소생술 및 자발순환 회복 후 심장 손상 및 혈역학을 연구하기 위한 새끼돼지 주산기 질식 모델

Transdermal Measurement of Glomerular Filtration Rate in Mice

Journal (Medicine)

Transdermal Measurement of Glomerular Filtration Rate in Mice

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Journal (Medicine)

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

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심정지, 소생술 및 자발순환 회복 후 심장 손상 및 혈역학을 연구하기 위한 새끼돼지 주산기 질식 모델

Article DOI: 10.3791/64788-v • 10:55 min • January 13th, 2023

January 13th, 2023 •

Eydis Oddsdottir Stenersen^1,2, Annette Olsen², Maria Melheim³, Rønnaug Solberg^3,4, Ingrid Dannevig⁵, Georg Schmölzer^6,7, Po-Yin Cheung^6,7, Britt Nakstad^8,9, Ola Didrik Saugstad^10,11, Arild Rønnestad^1,2, Anne Lee Solevåg²

¹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, ²Department of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ³Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ⁴Department of Pediatrics, Vestfold Hospital Trust, ⁵Department of Anesthesiology, Oslo University Hospital Rikshospitalet, ⁶Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, ⁷Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, ⁸Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, ⁹Department of Paediatrics and Adolescent Health, University of Botswana, ¹⁰Department of Pediatric Research, Oslo University Hospital, University of Oslo, ¹¹Department of Pediatrics, Robert H Lurie Medical Research Center, Northwestern University Chicago

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이 새끼 돼지 모델에는 수술 기구, 심정지까지 질식, 소생술 및 소생술 후 관찰이 포함됩니다. 이 모델은 동물당 다중 샘플링을 허용하고 지속적인 침습적 동맥 혈압, ECG 및 비침습적 심박출량 모니터링을 사용하여 주산기 질식 및 신생아 심폐소생술에서 혈역학 및 심장 병태생리학에 대한 지식을 제공합니다.

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