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Journal / Bioengineering / 测试通过微流控混合配制的mRNA-脂质纳米颗粒的 体外 和 体内…
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JoVE Journal Bioengineering
测试通过微流控混合配制的mRNA-脂质纳米颗粒的 体外 和 体内 效率
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测试通过微流控混合配制的mRNA-脂质纳米颗粒的 体外 和 体内 效率

Article DOI: 10.3791/64810-v • 08:55 min • January 20th, 2023
January 20th, 2023 •
1, 1, 1, 1, 1
1Department of Bioengineering, University of Pennsylvania

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在这里，提出了一种用于配制脂质纳米颗粒（LNP）的方案，该脂质纳米颗粒封装编码萤火虫荧光素酶的mRNA。这些 LNP 在体外 HepG2 细胞和体内 C57BL/6 小鼠中测试 了它们的效力。

Tags

生物工程，第 191 期，体外效率，体内效率，LNP，MRNA 货物，核酸酶降解，细胞内递送，可电离脂质，磷脂，胆固醇，脂质-PEG 偶联物，萤火虫荧光素酶，转染效率，HepG2 细胞，基于生物发光板的测定，C57BL/6 小鼠，静脉注射，侧尾静脉，全身生物发光成像，活体成像系统
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