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Udvikling af en kaninkronisk-lignende rotator manchetskademodel til undersøgelse af fibrose og muskulær fedtdegeneration
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Udvikling af en kaninkronisk-lignende rotator manchetskademodel til undersøgelse af fibrose og muskulær fedtdegeneration

Article DOI: 10.3791/64828-v • 05:20 min • March 31st, 2023
March 31st, 2023 •
1,2,3, 1,2, 1,2,3,4,5, 1,2,3,4,5
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 2Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, 3Center for Neuromusculoskeletal Restorative Medicine, The Chinese University of Hong Kong, 4Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, The Chinese University of Hong Kong, 5Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong

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Denne undersøgelse beskriver procedurer for etablering af en kronisk-lignende kanin rotator manchet (RC) skade. Specifikt er skaden skabt i subscapularis (SSC) muskel-sener / myotendinøs enhed for at efterligne human RC-anatomi og patofysiologi, herunder svær muskelfedtdegeneration (FD). Denne protokol kan anvendes til at studere RC-skader og vurdere regenerative terapier.

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Kanin kronisk-lignende rotator manchet skade model fibrose muskulær fedtdegeneration muskulatur sener styrke tilbagetrækning muskel-sener / myotendinøs enhed skulderfunktion RC reparationsresultater dyremodeller Human RC anatomi og patofysiologi vævsteknik Regenerativ medicin-baseret terapi Kanin subscapularis model Human supraspinatus knogle-senemuskel enhed fibrose og muskel fedtdegeneration (FD) kirurgiske procedurer isolering af SSC Coracobrachialis muskel Transsektion i fuld tykkelse silikonebaseret penroseslange histologisk evaluering
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