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A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
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JoVE Journal Chemistry
A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

DOI:
10.3791/64937-v

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05:21 min

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February 10, 2023

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, , , , ,
1Shenzhen Hwagen Pharmaceutical Co., Ltd, 2Guangdong Raffles Pharmaceutical Technology Co., Ltd

Chapters

  • 00:04Introduction
  • 00:46Continuous Flow Equipment Setup, Safety Check, and Leak Test
  • 02:29Continuous Flow Reaction Process
  • 03:29Results: Effect of Temperature and Residence Time on Continuous Flow Reaction
  • 04:33Conclusion

Summary

Automatic Translation

Automatic Translation

A detailed scalable continuous flow protocol is presented to synthesize an aryl fluoride from an aryl amine through the Balz-Schiemann reaction.

Tags

Keywords: Balz-Schiemann ReactionContinuous Flow ReactorAryl FluorideAryl AmineFine Chemical IndustryPharmaceutical IndustryMicroflow ReactorDynamic Mixing Tube ReactorTemperature RegulationSafetyLeakage CheckSteady State EquilibriumProduct Collection

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