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Mitokondriyal Metabolizma incelenmesi için Platform olarak İnsan Trombositler LC-MS Analizi
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Mitokondriyal Metabolizma incelenmesi için Platform olarak İnsan Trombositler LC-MS Analizi

Article DOI: 10.3791/53941-v • 06:04 min • April 4th, 2016
April 4th, 2016 •
*1,2, *2,3, 1,2, 2,3, 2,3, 4, 4, 1,2, 5, 1,2
1Center for Cancer Pharmacology, University of Pennsylvania, 2Center for Excellence in Environmental Toxicology, University of Pennsylvania, 3Penn SRP and Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 4Division of Traumatology, Department of Surgery, Critical Care and Acute Care Surgery, University of Pennsylvania, 5A.J. Drexel Autism Institute, Drexel University
* These authors contributed equally

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Burada izole edilmiş insan trombosit Ben rotenone inhibitör kompleksi cevaben metabolik uyarlamalar incelemek için ex vivo olarak erişilebilir bir şekilde modeli kullanılabilir göstermektedir. Bu yaklaşım, sıvı kromatografisi-kütle spektrometrisi ile izotopik izleme ve nispi miktarını kullanır ve çalışma düzeni, çeşitli uygulanabilir.

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Çevre Bilimleri Sayı 110 Metabolizma izotop izleyiciler trombositler kütle spektrometresi mitokondri rotenone ksenobiyotikler
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