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Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
JoVE Journal
Medicine
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JoVE Journal Medicine
Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
DOI:

10:31 min

August 13, 2017

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Chapters

  • 00:00Title
  • 00:16Introduction
  • 01:40Basic Principles of the Surgical Procedure
  • 03:18Presurgical Preparations
  • 03:53Harvest of a Vascularized Tibial Bone Segement (Bone VCA)
  • 06:24Orthotopic Tibial Bone VCA Reconstruction
  • 07:23Central Venous Catheter Placement
  • 07:54Postoperative Treatment and Follow Up
  • 08:46Results
  • 09:51Conclusion

Summary

Automatic Translation

Currently any kind of vascularized composite allotransplantation depends on long-term-immunosuppression, difficult to support for non-life-critical indications. We present a new porcine tibial VCA model that can be used to study bone VCA and demonstrate the use of surgical angiogenesis to maintain bone viability without the need of long-term immune-modulation.

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