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Intero Genome Sequencing di glabrata del Candida per rilevazione di marcatori di antifungini farmaco resistenza
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Intero Genome Sequencing di glabrata del Candida per rilevazione di marcatori di antifungini farmaco resistenza

Article DOI: 10.3791/56714-v • 08:46 min • December 28th, 2017
December 28th, 2017 •
*1, *1,2,3, 1,2, 1, 1, 1, 1, 1, 1, 4, 4,5, 6, 7, 1,3, 1,2,3
1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre
* These authors contributed equally

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Questo studio ha implementato il sequenziamento del genoma intero per l'analisi di mutazioni in geni che conferiscono resistenza ai farmaci antifungini in glabrata del Candida. Glabrata del c. isolati resistenti agli echinocandine, azoli e 5-flucitosina, sono stati sequenziati per illustrare la metodologia. Profili di predisposizione degli isolati correlata con la presenza o l'assenza di modelli specifici di mutazione nei geni.

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Medicina problema 130 glabrata del Candida sequenziamento dell'intero genoma resistenza ai farmaci antifungini echinocandine azoli 5-flucitosina genome-wide analisi
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