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JoVE Journal Chemistry
Pretargeted Radioimmunotherapy baseado na reação de Diels-Alder de demanda inversa elétron
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Pretargeted Radioimmunotherapy baseado na reação de Diels-Alder de demanda inversa elétron

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Este protocolo descreve a síntese e caracterização de um trans- cyclooctene (TCO)-anticorpo e uma 177tetrazine Lu-rotulado (Tz) radioligantes para pretargeted radioimmunotherapy (Thayse) modificados. Além disso, ele detalha o uso dessas duas construções para na vivo biodistribuição e estudos longitudinais terapia em um modelo murino de câncer colorretal.

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Química questão 143 radioimmunotherapy radioimmunotherapy pretargeted pretargeting reação de Diels-Alder de demanda inversa elétron tetrazine trans- cyclooctene huA33 antígeno A33 lutécio-177
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