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Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
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JoVE Journal Medicine
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

DOI:
10.3791/59646-v

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05:08 min

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October 03, 2019

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, , , , ,
1Department of Anesthesiology,University of California, 2Department of Medicine,University of California, 3Department of Microbiology, Immunology & Molecular Genetics,University of California, 4Department of Molecular, Cell, and Developmental Biology,University of California

Chapters

  • 00:04Title
  • 00:40Isoproterenol (ISO) Osmotic Pump Preparation
  • 02:00ISO Osmotic Pump Surgical Implantation
  • 03:17Results: Representative Changes in Echocardiographic Measures in Different Mouse Strains and After Isoproterenol
  • 04:06Conclusion

Summary

Automatic Translation

Automatic Translation

The chronic administration of isoproterenol via an implanted osmotic pump has been used widely to mimic advanced heart failure in mice. Here, we describe detailed methods in surgical mini-pump implantation for the continuous isoproterenol administration over 3 weeks, as well as, echocardiographic assessment for the successful model creation.

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