Lilin Ye Institute of Immunology Third Military Medical University Biography Publications Institution JoVE Articles Lilin Ye has not added a biography. If you are Lilin Ye and would like to personalize this page please email our Author Liaison for assistance. Publications An Oncolytic Virus Delivering Tumor-irrelevant Bystander T Cell Epitopes Induces Anti-tumor Immunity and Potentiates Cancer Immunotherapy Nature Cancer. Apr, 2024 | Pubmed ID: 38609488 Bile Acids Modified by the Intestinal Microbiota Promote Colorectal Cancer Growth by Suppressing CD8 T cell Effector Functions Immunity. Apr, 2024 | Pubmed ID: 38479384 Role of Tumor Cell Pyroptosis in Anti-tumor Immunotherapy Cell Insight. Jun, 2024 | Pubmed ID: 38464416 Functional Diversification and Dynamics of CAR-T Cells in Patients with B-ALL Cell Reports. Oct, 2023 | Pubmed ID: 37851569 The Role of CD4 T Cells in Tumor and Chronic Viral Immune Responses MedComm. Oct, 2023 | Pubmed ID: 37829505 Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity Journal of Immunology (Baltimore, Md. : 1950). Nov, 2023 | Pubmed ID: 37728417 Aged Hematopoietic Stem Cells Entrap Regulatory T Cells to Create a Prosurvival Microenvironment Cellular & Molecular Immunology. Oct, 2023 | Pubmed ID: 37644165 The TRIM37 Variants in Mulibrey Nanism Patients Paralyze Follicular Helper T Cell Differentiation Cell Discovery. Aug, 2023 | Pubmed ID: 37528081 An RBD Bispecific Antibody Effectively Neutralizes a SARS-CoV-2 Omicron Variant One Health Advances. 2023 | Pubmed ID: 37521533 PD-1/PD-L1 Blockade Restores Tumor-induced COVID-19 Vaccine Bluntness Vaccine. Jul, 2023 | Pubmed ID: 37400286 Author Correction: Tumor-specific Memory CD8 T Cells Are Strictly Resident in Draining Lymph Nodes During Tumorigenesis Cellular & Molecular Immunology. Jul, 2023 | Pubmed ID: 37225839 The G Allele of SNP Rs3922 Reduces the Binding Affinity Between IGF2BP3 and CXCR5 Correlating with a Lower Antibody Production European Journal of Immunology. Aug, 2023 | Pubmed ID: 37141498 Identification and Comparison of the Sialic Acid-Binding Domain Characteristics of Avian Coronavirus Infectious Bronchitis Virus Spike Protein Journal of Virology. May, 2023 | Pubmed ID: 37097156 A Novel MAb Broadly Neutralizes SARS-CoV-2 VOCs in Vitro and in Vivo, Including the Omicron Variants Journal of Medical Virology. Mar, 2023 | Pubmed ID: 36912367 Tumor-specific Memory CD8 T Cells Are Strictly Resident in Draining Lymph Nodes During Tumorigenesis Cellular & Molecular Immunology. Apr, 2023 | Pubmed ID: 36859455 Mechanisms of Antigen-induced Reversal of CNS Inflammation in Experimental Demyelinating Disease Science Advances. Mar, 2023 | Pubmed ID: 36857453 Dopamine Inhibits Group 2 Innate Lymphoid Cell-driven Allergic Lung Inflammation by Dampening Mitochondrial Activity Immunity. Feb, 2023 | Pubmed ID: 36693372 Bound to Be Perfect: Lck and T Cell Co-receptors Nature Immunology. Jan, 2023 | Pubmed ID: 36596893 The Land-scape of Immune Response to Monkeypox Virus EBioMedicine. Jan, 2023 | Pubmed ID: 36584594 Nasal Spray of Neutralizing Monoclonal Antibody 35B5 Confers Potential Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Small-Scale Clinical Trial Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2023 | Pubmed ID: 35666466 Role of CXCR5 CD8 T Cells in Human Immunodeficiency Virus-1 Infection Frontiers in Microbiology. 2022 | Pubmed ID: 36452930 The M1A Modification of TRNAs: a Translational Accelerator of T-cell Activation Cellular & Molecular Immunology. Dec, 2022 | Pubmed ID: 36336727 The Primordial Differentiation of Tumor-specific Memory CD8 T cells As Bona Fide Responders to PD-1/PD-L1 Blockade in Draining Lymph Nodes Cell. Oct, 2022 | Pubmed ID: 36208623 EZH2 Restricts DNA Methylation and Promotes T Differentiation During Acute Viral Infection Frontiers in Immunology. 2022 | Pubmed ID: 36045674 A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern Journal of Virology. Aug, 2022 | Pubmed ID: 35916510 The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells Frontiers in Cellular and Infection Microbiology. 2022 | Pubmed ID: 35909969 Tumor-Specific CD4 T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4 T Cells Frontiers in Immunology. 2022 | Pubmed ID: 35784297 CD4 T-cell Epitope-based Heterologous Prime-boost Vaccination Potentiates Anti-tumor Immunity and PD-1/PD-L1 Immunotherapy Journal for Immunotherapy of Cancer. May, 2022 | Pubmed ID: 35580929 35B5 Antibody Potently Neutralizes SARS-CoV-2 Omicron by Disrupting the N-glycan Switch Via a Conserved Spike Epitope Cell Host & Microbe. Jun, 2022 | Pubmed ID: 35436443 A Novel Strategy to Investigate the Factors Regulating the Treg to Tfr Transition During Acute Viral Infection Journal of Immunological Methods. Jun, 2022 | Pubmed ID: 35398062 A Potent Human Monoclonal Antibody with Pan-neutralizing Activities Directly Dislocates S Trimer of SARS-CoV-2 Through Binding Both Up and Down Forms of RBD Signal Transduction and Targeted Therapy. Apr, 2022 | Pubmed ID: 35383141 Prompt Antiviral Action of Pulmonary CD8+ T Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung Frontiers in Immunology. 2022 | Pubmed ID: 35296070 Differential Expression of Inhibitory Receptor NKG2A Distinguishes Disease-specific Exhausted CD8 T Cells MedComm. Mar, 2022 | Pubmed ID: 35281793 The Kinase Complex MTORC2 Promotes the Longevity of Virus-specific Memory CD4 T Cells by Preventing Ferroptosis Nature Immunology. Feb, 2022 | Pubmed ID: 34949833 A Novel Linear and Broadly Neutralizing Peptide in the SARS-CoV-2 S2 Protein for Universal Vaccine Development Cellular & Molecular Immunology. Nov, 2021 | Pubmed ID: 34645942 Sensitivity of SARS-CoV-2 Variants to Neutralization by Convalescent Sera and a VH3-30 Monoclonal Antibody Frontiers in Immunology. 2021 | Pubmed ID: 34630430 The Metabolic Hormone Leptin Promotes the Function of T Cells and Supports Vaccine Responses Nature Communications. 05, 2021 | Pubmed ID: 34031386 The LncRNA Snhg1-Vps13D Vesicle Trafficking System Promotes Memory CD8 T Cell Establishment Via Regulating the Dual Effects of IL-7 Signaling Signal Transduction and Targeted Therapy. 03, 2021 | Pubmed ID: 33758164 The Dichotomous and Incomplete Adaptive Immunity in COVID-19 Patients with Different Disease Severity Signal Transduction and Targeted Therapy. 03, 2021 | Pubmed ID: 33686064 METTL3-dependent MA Modification Programs T Follicular Helper Cell Differentiation Nature Communications. 02, 2021 | Pubmed ID: 33637761 DAPK1 (death Associated Protein Kinase 1) Mediates MTORC1 Activation and Antiviral Activities in CD8 T Cells Cellular & Molecular Immunology. Jan, 2021 | Pubmed ID: 31541182 The Epigenetic Regulator EZH2 Instructs CD4 T Cell Response to Acute Viral Infection Via Coupling of Cell Expansion and Metabolic Fitness Journal of Virology. 11, 2020 | Pubmed ID: 32999031 Disease Severity Dictates SARS-CoV-2-specific Neutralizing Antibody Responses in COVID-19 Signal Transduction and Targeted Therapy. 09, 2020 | Pubmed ID: 32879307 Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis Frontiers in Immunology. 2020 | Pubmed ID: 32477338 CD49aCD49b NK Cells Induced by Viral Infection Reflect an Activated State of Conventional NK Cells Science China. Life Sciences. Nov, 2020 | Pubmed ID: 32335843 Human Monoclonal Antibodies Block the Binding of SARS-CoV-2 Spike Protein to Angiotensin Converting Enzyme 2 Receptor Cellular & Molecular Immunology. 06, 2020 | Pubmed ID: 32313207 Improving the Immunogenicity and Protective Efficacy of a Whole-killed Malaria Blood-stage Vaccine by Chloroquine Parasite Immunology. 01, 2020 | Pubmed ID: 31644820 T Cell Immune Response Within B-cell Follicles Advances in Immunology. 2019 | Pubmed ID: 31699216 ZIKV Infection Induces Robust Th1-like Tfh Cell and Long-term Protective Antibody Responses in Immunocompetent Mice Nature Communications. 08, 2019 | Pubmed ID: 31455769 Sclerostin Domain-containing Protein 1 is Dispensable for the Differentiation of Follicular Helper and Follicular Regulatory T Cells During Acute Viral Infection American Journal of Translational Research. 2019 | Pubmed ID: 31312383 Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8 T Cells in Acute Viral Infection Journal of Immunology (Baltimore, Md. : 1950). 07, 2019 | Pubmed ID: 31175159 The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection Frontiers in Immunology. 2019 | Pubmed ID: 30984183 Ceria Nanoparticles Promoted the Cytotoxic Activity of CD8 T Cells by Activating NF-κB Signaling Biomaterials Science. May, 2019 | Pubmed ID: 30968875 The Histone Methyltransferase EZH2 Primes the Early Differentiation of Follicular Helper T Cells During Acute Viral Infection Cellular & Molecular Immunology. Mar, 2019 | Pubmed ID: 30842630 Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4 T Cells Frontiers in Immunology. 2019 | Pubmed ID: 30828337 The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection Frontiers in Immunology. 2019 | Pubmed ID: 30814995 Genome-wide Analysis Identifies NR4A1 As a Key Mediator of T Cell Dysfunction Nature. 03, 2019 | Pubmed ID: 30814730 Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells Via the PD-1-PD-L1 Axis Immunity. 02, 2019 | Pubmed ID: 30709740 Crosstalks Between MTORC1 and MTORC2 Variagate Cytokine Signaling to Control NK Maturation and Effector Function Nature Communications. 11, 2018 | Pubmed ID: 30451838 A Portrait of CXCR5 Follicular Cytotoxic CD8 T Cells Trends in Immunology. 12, 2018 | Pubmed ID: 30377045 Late-stage Tumors Induce Anemia and Immunosuppressive Extramedullary Erythroid Progenitor Cells Nature Medicine. 10, 2018 | Pubmed ID: 30297899 B7S1, a Novel Candidate for Anti-tumor Checkpoint Blockade Immunotherapy Science China. Life Sciences. Sep, 2018 | Pubmed ID: 30069671 The Kinase Complex MTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4 T Cells During Viral Infection Frontiers in Immunology. 2018 | Pubmed ID: 29875775 Differentiation and Function of Follicular CD8 T Cells During Human Immunodeficiency Virus Infection Frontiers in Immunology. 2018 | Pubmed ID: 29872434 Patient-shared TCRβ-CDR3 Clonotypes Correlate with Favorable Prognosis in Chronic Hepatitis B European Journal of Immunology. 09, 2018 | Pubmed ID: 29856484 Flow Cytometry Analysis of MTOR Signaling in Antigen-Specific B Cells Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29388102 Analyzing Mouse B Cell Responses Specific to LCMV Infection Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29388097 Efficient Control of Chronic LCMV Infection by a CD4 T Cell Epitope-based Heterologous Prime-boost Vaccination in a Murine Model Cellular & Molecular Immunology. 09, 2018 | Pubmed ID: 28287115 Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5 and CXCR5 CD8 T Cells During Chronic HIV Infection Frontiers in Immunology. 2017 | Pubmed ID: 29312314 The Kinase MTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells Immunity. 09, 2017 | Pubmed ID: 28930662 The Differential Organogenesis and Functionality of Two Liver-draining Lymph Nodes in Mice Journal of Autoimmunity. Nov, 2017 | Pubmed ID: 28886898 Oral Administration of Visceral Adipose Tissue Antigens Ameliorates Metabolic Disorders in Mice and Elevates Visceral Adipose Tissue-resident CD4CD25Foxp3 Regulatory T Cells Vaccine. 08, 2017 | Pubmed ID: 28736203 Mammalian Target of Rapamycin Complex 1 Signalling is Essential for Germinal Centre Reaction Immunology. 10, 2017 | Pubmed ID: 28557002 Antigen-specific CD8 T Cell Feedback Activates NLRP3 Inflammasome in Antigen-presenting Cells Through Perforin Nature Communications. 05, 2017 | Pubmed ID: 28537251 MTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses Journal of Virology. 02, 2017 | Pubmed ID: 27974559 ABHD5 Interacts with BECN1 to Regulate Autophagy and Tumorigenesis of Colon Cancer Independent of PNPLA2 Autophagy. 11, 2016 | Pubmed ID: 27559856 Follicular CXCR5- Expressing CD8(+) T Cells Curtail Chronic Viral Infection Nature. 08, 2016 | Pubmed ID: 27501245 The Transcription Factor TCF-1 Initiates the Differentiation of T(FH) Cells During Acute Viral Infection Nature Immunology. Sep, 2015 | Pubmed ID: 26214740 Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice Yao Lin*1,2, Shuai Yue*3, Yang Yang*4, Junjian He5, Xiaofan Yang6, Lilin Ye5, Xiangyu Chen7 1Department of Urology, South China Hospital, Medical School, Shenzhen University, 2Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, 3Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University, 4Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, 5Institute of Immunology, Third Military Medical University, 6Dermatology Hospital, Southern Medical University, 7Institute of Immunological Innovation and Translation, Chongqing Medical University JoVE 66752 Immunology and Infection Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis Yan Zhang*1, Xingxing Su*2, Lisha Wang2, Zhengliang Yue2, Qiao Liu3, Ling Ran2, Shun Lei2, Jianjun Hu2, Lifan Xu2, Lilin Ye2, Ping Ji4, Guimei Li1, Qizhao Huang5, Shuqiong Wen4 1College of Veterinary Medicine, Qingdao Agricultural University, 2Institute of Immunology, Third Military Medical University, 3Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 4Stomatological Hospital of Chongqing Medical University, 5Institute of life science, Chongqing Medical University JoVE 65646 Immunology and Infection Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice Lisha Wang1, Zhiming Wang1, Junyi Guo2, Huayu Lin1, Shuqiong Wen2, Qiao Liu1, Yiding Li3, Qing Wu1, Leiqiong Gao1, Xiangyu Chen1, Luoyingzi Xie1, Qin Tian1, Jianfang Tang1, Zhirong Li1, Li Hu1, Juan Wang4, Lifan Xu1, Qizhao Huang5, Lilin Ye1 1Institute of Immunology, Third Military Medical University, 2Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Stomatological Hospital, Sun Yat-Sen University, 3Shigatse Branch, Xinqiao Hospital, Third Military Medical University, 4Department of Emergency Medicine, Southwest Hospital, Third Military Medical University, 5Cancer Center, The General Hospital of Western Theater Command JoVE 62442 Cancer Research
Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice Yao Lin*1,2, Shuai Yue*3, Yang Yang*4, Junjian He5, Xiaofan Yang6, Lilin Ye5, Xiangyu Chen7 1Department of Urology, South China Hospital, Medical School, Shenzhen University, 2Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, 3Cancer Center, Daping Hospital & Army Medical Center of PLA, Third Military Medical University, 4Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, 5Institute of Immunology, Third Military Medical University, 6Dermatology Hospital, Southern Medical University, 7Institute of Immunological Innovation and Translation, Chongqing Medical University JoVE 66752 Immunology and Infection
Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis Yan Zhang*1, Xingxing Su*2, Lisha Wang2, Zhengliang Yue2, Qiao Liu3, Ling Ran2, Shun Lei2, Jianjun Hu2, Lifan Xu2, Lilin Ye2, Ping Ji4, Guimei Li1, Qizhao Huang5, Shuqiong Wen4 1College of Veterinary Medicine, Qingdao Agricultural University, 2Institute of Immunology, Third Military Medical University, 3Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 4Stomatological Hospital of Chongqing Medical University, 5Institute of life science, Chongqing Medical University JoVE 65646 Immunology and Infection
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice Lisha Wang1, Zhiming Wang1, Junyi Guo2, Huayu Lin1, Shuqiong Wen2, Qiao Liu1, Yiding Li3, Qing Wu1, Leiqiong Gao1, Xiangyu Chen1, Luoyingzi Xie1, Qin Tian1, Jianfang Tang1, Zhirong Li1, Li Hu1, Juan Wang4, Lifan Xu1, Qizhao Huang5, Lilin Ye1 1Institute of Immunology, Third Military Medical University, 2Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Stomatological Hospital, Sun Yat-Sen University, 3Shigatse Branch, Xinqiao Hospital, Third Military Medical University, 4Department of Emergency Medicine, Southwest Hospital, Third Military Medical University, 5Cancer Center, The General Hospital of Western Theater Command JoVE 62442 Cancer Research
