Lynne Howells

Publications

• Risk of Cancer Incidence and Mortality Associated with Diabetes: A Systematic Review with Trend Analysis of 203 Cohorts
  Nutrition, Metabolism, and Cardiovascular Diseases : NMCD. Jan, 2021  |   Pubmed ID: 33223399
• Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020  |   Pubmed ID: 33318618
• Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People
  Diabetes Care. Sep, 2020  |   Pubmed ID: 32910779
• Myeloid Derived Suppressor Cells Are Reduced and T Regulatory Cells Stabilised in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine and Intravenous Omega 3
  Annals of Translational Medicine. Mar, 2020  |   Pubmed ID: 32309319
• New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells
  Molecules (Basel, Switzerland). Jan, 2020  |   Pubmed ID: 31963196
• Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery
  British Journal of Cancer. 03, 2020  |   Pubmed ID: 31894140
• Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial
  The Journal of Nutrition. 07, 2019  |   Pubmed ID: 31132111
• Circulating Tumor DNA in Patients with Colorectal Adenomas: Assessment of Detectability and Genetic Heterogeneity
  Cell Death & Disease. 08, 2018  |   Pubmed ID: 30166531
• Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
  Scientific Reports. 08, 2018  |   Pubmed ID: 30108309
• Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers
  Molecular Nutrition & Food Research. 08, 2018  |   Pubmed ID: 29943914
• An HPLC-UV Method for the Simultaneous Quantification of Curcumin and Its Metabolites in Plasma and Lung Tissue: Potential for Preclinical Applications
  Biomedical Chromatography : BMC. May, 2018  |   Pubmed ID: 29744910
• Effects of Omegaven®, EPA, DHA and Oxaliplatin on Oesophageal Adenocarcinoma Cell Lines Growth, Cytokine and Cell Signal Biomarkers Expression
  Lipids in Health and Disease. Jan, 2018  |   Pubmed ID: 29378575
• Assessing Barriers to a Rational Chemoprevention Trial Design in Young Patients with Familial Adenomatous Polyposis
  European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). 07, 2017  |   Pubmed ID: 27128580
• Curcumin Mediates Oxaliplatin-acquired Resistance Reversion in Colorectal Cancer Cell Lines Through Modulation of CXC-Chemokine/NF-κB Signalling Pathway
  Scientific Reports. Apr, 2016  |   Pubmed ID: 27091625
• Targeting Cancer Stem-like Cells Using Dietary-derived Agents - Where Are We Now?
  Molecular Nutrition & Food Research. 06, 2016  |   Pubmed ID: 27060283
• Targeting Pancreatic Cancer Using a Combination of Gemcitabine with the Omega-3 Polyunsaturated Fatty Acid Emulsion, Lipidem™
  Molecular Nutrition & Food Research. 06, 2016  |   Pubmed ID: 26603273
• The Role of Stromal Fibroblasts in Lung Carcinogenesis: A Target for Chemoprevention?
  International Journal of Cancer. Jan, 2016  |   Pubmed ID: 25611701
• Cancer Chemoprevention: Evidence of a Nonlinear Dose Response for the Protective Effects of Resveratrol in Humans and Mice
  Science Translational Medicine. Jul, 2015  |   Pubmed ID: 26223300
• Inhibition of Prostate Cancer Cell Growth by 3',4',5'-trimethoxyflavonol (TMFol)
  Cancer Chemotherapy and Pharmacology. Jul, 2015  |   Pubmed ID: 26017621
• Curcumin Inhibits Cancer Stem Cell Phenotypes in Ex Vivo Models of Colorectal Liver Metastases, and is Clinically Safe and Tolerable in Combination with FOLFOX Chemotherapy
  Cancer Letters. Aug, 2015  |   Pubmed ID: 25979230
• Combining Curcumin (C3-complex, Sabinsa) with Standard Care FOLFOX Chemotherapy in Patients with Inoperable Colorectal Cancer (CUFOX): Study Protocol for a Randomised Control Trial
  Trials. Mar, 2015  |   Pubmed ID: 25872567
• Characterization and Propagation of Tumor Initiating Cells Derived from Colorectal Liver Metastases: Trials, Tribulations and a Cautionary Note
  PloS One. 2015  |   Pubmed ID: 25658706
• Potential for Proteomic Approaches in Determining Efficacy Biomarkers Following Administration of Fish Oils Rich in Omega-3 Fatty Acids: Application in Pancreatic Cancers
  Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition. Jun, 2015  |   Pubmed ID: 25616520
• Cancer Chemoprevention: Factors Influencing Attitudes Towards Chemopreventive Agents in High-risk Populations
  European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP). Nov, 2014  |   Pubmed ID: 25259886
• Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
  The Journal of Pharmacology and Experimental Therapeutics. Sep, 2014  |   Pubmed ID: 24939419
• The Role of Cancer Stem Cells in the Anti-carcinogenicity of Curcumin
  Molecular Nutrition & Food Research. Sep, 2013  |   Pubmed ID: 23900994
• Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration--a Clinical Pilot Study Including Assessment of Patient Acceptability
  Cancer Prevention Research (Philadelphia, Pa.). Feb, 2013  |   Pubmed ID: 23233733
• Phase I Randomized, Double-blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases--safety, Pharmacokinetics, and Pharmacodynamics
  Cancer Prevention Research (Philadelphia, Pa.). Sep, 2011  |   Pubmed ID: 21680702
• Curcumin Ameliorates Oxaliplatin-induced Chemoresistance in HCT116 Colorectal Cancer Cells in Vitro and in Vivo
  International Journal of Cancer. Jul, 2011  |   Pubmed ID: 20839263
• Preclinical Colorectal Cancer Chemopreventive Efficacy and P53-modulating Activity of 3',4',5'-trimethoxyflavonol, a Quercetin Analogue
  Cancer Prevention Research (Philadelphia, Pa.). Aug, 2010  |   Pubmed ID: 20628003
• Indole-3-carbinol Enhances Anti-proliferative, but Not Anti-invasive Effects of Oxaliplatin in Colorectal Cancer Cell Lines
  Biochemical Pharmacology. May, 2008  |   Pubmed ID: 18358454
• Predicting the Physiological Relevance of in Vitro Cancer Preventive Activities of Phytochemicals
  Acta Pharmacologica Sinica. Sep, 2007  |   Pubmed ID: 17723163
• Comparison of Oxaliplatin- and Curcumin-mediated Antiproliferative Effects in Colorectal Cell Lines
  International Journal of Cancer. Jul, 2007  |   Pubmed ID: 17330230
• Involvement of Nrf2, P38, B-Raf, and Nuclear Factor-kappaB, but Not Phosphatidylinositol 3-kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols
  Molecular Pharmacology. Mar, 2006  |   Pubmed ID: 16354769
• Inhibition of Phosphatidylinositol 3-kinase/protein Kinase B Signaling is Not Sufficient to Account for Indole-3-carbinol-induced Apoptosis in Some Breast and Prostate Tumor Cells
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2005  |   Pubmed ID: 16322316
• Prospects for Plant-derived Chemopreventive Agents Exhibiting Multiple Mechanisms of Action
  Current Medicinal Chemistry. Anti-cancer Agents. May, 2005  |   Pubmed ID: 15992350
• Relevance of Mitogen Activated Protein Kinase (MAPK) and Phosphotidylinositol-3-kinase/protein Kinase B (PI3K/PKB) Pathways to Induction of Apoptosis by Curcumin in Breast Cells
  Biochemical Pharmacology. Feb, 2003  |   Pubmed ID: 12527329
• Growth-inhibitory Effects of the Chemopreventive Agent Indole-3-carbinol Are Increased in Combination with the Polyamine Putrescine in the SW480 Colon Tumour Cell Line
  BMC Cancer. Jan, 2003  |   Pubmed ID: 12525265
• Indole-3-carbinol Inhibits Protein Kinase B/Akt and Induces Apoptosis in the Human Breast Tumor Cell Line MDA MB468 but Not in the Nontumorigenic HBL100 Line
  Molecular Cancer Therapeutics. Nov, 2002  |   Pubmed ID: 12479697