Marion MacFarlane

Publications

• Development of a Patient-derived Explant Model for Prediction of Drug Responses in Endometrial Cancer
  Gynecologic Oncology. Feb, 2021  |   Pubmed ID: 33309417
• Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020  |   Pubmed ID: 33318618
• Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors
  Analytical Chemistry. 07, 2020  |   Pubmed ID: 32545955
• Identification of a Novel Toxicophore in Anti-cancer Chemotherapeutics That Targets Mitochondrial Respiratory Complex I
  ELife. 05, 2020  |   Pubmed ID: 32432547
• Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery
  British Journal of Cancer. 03, 2020  |   Pubmed ID: 31894140
• Patient-derived Explants, Xenografts and Organoids: 3-dimensional Patient-relevant Pre-clinical Models in Endometrial Cancer
  Gynecologic Oncology. 01, 2020  |   Pubmed ID: 31767187
• Evaluation of Apoptosis Imaging Biomarkers in a Genetic Model of Cell Death
  EJNMMI Research. Feb, 2019  |   Pubmed ID: 30783791
• Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials
  Chemical Research in Toxicology. 10, 2018  |   Pubmed ID: 30156102
• N-glycosylation of Mouse TRAIL-R Restrains TRAIL-induced Apoptosis
  Cell Death & Disease. 05, 2018  |   Pubmed ID: 29717117
• Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018
  Cell Death and Differentiation. Mar, 2018  |   Pubmed ID: 29362479
• Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
  Current Biology : CB. Nov, 2017  |   Pubmed ID: 29112861
• Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival
  Cell Reports. 04, 2017  |   Pubmed ID: 28445729
• Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy
  Cancer Research. 04, 2017  |   Pubmed ID: 28202521
• Targeting Cell Death Signalling in Cancer: Minimising 'Collateral Damage'
  British Journal of Cancer. Jun, 2016  |   Pubmed ID: 27140313
• Co-operative and Hierarchical Binding of C-FLIP and Caspase-8: A Unified Model Defines How C-FLIP Isoforms Differentially Control Cell Fate
  Molecular Cell. Mar, 2016  |   Pubmed ID: 26990987
• Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex
  Cold Spring Harbor Protocols. Dec, 2015  |   Pubmed ID: 26631130
• Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex
  Cold Spring Harbor Protocols. Dec, 2015  |   Pubmed ID: 26631122
• In Vitro Assembly and Analysis of the Apoptosome Complex
  Cold Spring Harbor Protocols. Dec, 2015  |   Pubmed ID: 26631121
• Autophagy Limits Proliferation and Glycolytic Metabolism in Acute Myeloid Leukemia
  Cell Death Discovery. Aug, 2015  |   Pubmed ID: 26568842
• Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells
  Journal of Cellular Biochemistry. Jul, 2015  |   Pubmed ID: 25704336
• Isolation, Characterisation and Reconstitution of Cell Death Signalling Complexes
  Methods (San Diego, Calif.). Jun, 2013  |   Pubmed ID: 23485576
• Glucose--a Sweet Way to Die: Metabolic Switching Modulates Tumor Cell Death
  Cell Cycle (Georgetown, Tex.). Nov, 2012  |   Pubmed ID: 22983094
• A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
  Molecular Cell. Jul, 2012  |   Pubmed ID: 22683266
• The 'complexities' of Life and Death: Death Receptor Signalling Platforms
  Experimental Cell Research. Jul, 2012  |   Pubmed ID: 22542855
• CIAPs Block Ripoptosome Formation, a RIP1/caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by CFLIP Isoforms
  Molecular Cell. Aug, 2011  |   Pubmed ID: 21737330
• Mitochondrial Fragmentation and Neuronal Cell Death in Response to the Bcl-2/Bcl-x(L)/Bcl-w Antagonist ABT-737
  Neuropharmacology. Jun, 2010  |   Pubmed ID: 20307556
• Cell Death Pathways--potential Therapeutic Targets
  Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Aug, 2009  |   Pubmed ID: 19622004
• Recombinant TRAIL and TRAIL Receptor Analysis
  Methods in Enzymology. 2008  |   Pubmed ID: 18603130
• TRAIL Signals to Apoptosis in Chronic Lymphocytic Leukaemia Cells Primarily Through TRAIL-R1 Whereas Cross-linked Agonistic TRAIL-R2 Antibodies Facilitate Signalling Via TRAIL-R2
  British Journal of Haematology. Nov, 2007  |   Pubmed ID: 17922877
• Apoptosis and Disease: a Life or Death Decision
  EMBO Reports. Jul, 2004  |   Pubmed ID: 15218528
• Caspase Activation Inhibits Proteasome Function During Apoptosis
  Molecular Cell. Apr, 2004  |   Pubmed ID: 15068805
• TRAIL-induced Signalling and Apoptosis
  Toxicology Letters. Apr, 2003  |   Pubmed ID: 12628743
• Mechanisms of Resistance to TRAIL-induced Apoptosis in Primary B Cell Chronic Lymphocytic Leukaemia
  Oncogene. Oct, 2002  |   Pubmed ID: 12360407
• C-Myc Protein Synthesis is Initiated from the Internal Ribosome Entry Segment During Apoptosis
  Molecular and Cellular Biology. Feb, 2000  |   Pubmed ID: 10648601