Induction and Evaluation of Experimental Autoimmune Encephalomyelitis in Mouse

October 13th, 2023

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Brigitta Bonaldo^1,2, Antonino Casile^1,2,3, Francesca Montarolo^1,2, Antonio Bertolotto^1,4

¹Neuroscience Institute Cavalieri Ottolenghi (NICO), ²Department of Neuroscience “Rita Levi-Montalcini”, University of Turin, ³School of Pharmacy, Pharmacology Unit, University of Camerino, ⁴Koelliker Hospital

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Eksperimentel autoimmun encephalomyelitis er en af de mest anvendte murinmodeller af multipel sklerose. I den nuværende protokol immuniseres C57BL/6J-mus af begge køn med myelinoligodendrocytglycoproteinpeptid, hvilket hovedsageligt resulterer i stigende parese af halen og lemmerne. Her diskuterer vi protokollen for EAE-induktion og evaluering.

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Induction and Evaluation of Experimental Autoimmune Encephalomyelitis in Mouse

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