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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Article DOI: 10.3791/3030-v • 08:46 min • September 29th, 2011
September 29th, 2011 •
1, 1, 1
1Andrus Gerontology Center, Department of Biological Sciences, Department of Molecular and Computational Biology, University of Southern California, Los Angeles

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Here we describe a set of DNA mutation assays that can be combined with the yeast chronological life span model to study the genes/pathways that regulate or contribute to genomic DNA instability during aging.

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Age-dependent Genomic Instability S. Cerevisiae Chronological Lifespan Model Saccharomyces Cerevisiae Aging Model Life Span Regulatory Pathways DNA Damage Genome Maintenance Diseases During Aging Age-dependent DNA Mutations Base Substitutions Frame-shift Mutations Gross Chromosomal Rearrangements Homologous Recombination Homeologous Recombination Nuclear DNA Repair Activity Yeast Chronological Life Span DNA Damage Assays Mutation Assays Genes/pathways That Regulate Genomic Instability Age-dependent DNA Mutations Cancer In Mammals
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