在体内病态的人类基因组建模使用斑马鱼
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August 24, 2013
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在这里，我们提出了一个系统的方法来开发有关生理，敏感，特异<em>在体内</em>分析用于解释人类病理学变化。瞬态的遗传操作，通过微量注射野生型和突变型人mRNA和吗啉代（MO）的反义寡核苷酸利用显影斑马鱼胚胎的快速检测致病突变，特别是，但不完全是，在人类发育障碍的上下文中的易处理性。
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Cite this Article
Niederriter, A. R., Davis, E. E., Golzio, C., Oh, E. C., Tsai, I., Katsanis, N. In Vivo Modeling of the Morbid Human Genome using Danio rerio. J. Vis. Exp. (78), e50338, doi:10.3791/50338 (2013).
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