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JoVE Journal Neuroscience
Bioluminesens Imaging av nevroinflammasjon i transgene mus etter Peripheral Inokulering av Alfa synukleinfibriller
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Bioluminesens Imaging av nevroinflammasjon i transgene mus etter Peripheral Inokulering av Alfa synukleinfibriller

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Perifer injeksjon av alfa-synukleinfibriller i peritoneum eller tunge av Tg (M83 +/-: GFAP -luc +/-) mus som uttrykker human alpha-synuclein med familiær A53T mutasjonen og ildflueluciferase, kan indusere neuropatologi, inkludert nevroinflammasjon , i deres sentralnervesystemet.

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Neuroscience utgave 122 Alpha-synuclein bioluminescens avbildning inflammasjon synucleinopathy neuroinvasion Parkinsons sykdom perifer prion-lignende prionoid
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