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A Mouse Model of in Utero Transplantation

Article DOI: 10.3791/2303-v • 09:11 min • January 27th, 2011
January 27th, 2011 •
1,2, 1,2, 1,2,3, 1,2,3
1Department of Surgery, University of California, 2Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 3Biomedical Sciences Program, University of California

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The mouse model of in utero transplantation is a versatile tool that can be used to study the potential clinical applications of stem cell transplantation and gene therapy in the fetus. In this protocol, we present a general approach to performing this technique

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In Utero Transplantation Stem Cells Viruses Congenital Disorders Human Fetus Hematopoietic Stem Cells Severe Combined Immunodeficiency Non-human Model Gene Therapy Successful Engraftment Wild-type Mice Genetic Diseases Fetal Environment Adenoviral Vectors Adeno-associated Viral Vectors Retroviral Vectors Lentiviral Vectors In Utero Gene Therapy Single Gene Disorders Muscular Dystrophy Cystic Fibrosis Immune Tolerance
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