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Journal / Bioengineering / Gentranskription durch Umleiten zellulären…
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Bioengineering

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JoVE Journal Bioengineering
Gentranskription durch Umleiten zellulären Maschinerie mit chemischen epigenetische Modifikatoren zu unterdrücken
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Gentranskription durch Umleiten zellulären Maschinerie mit chemischen epigenetische Modifikatoren zu unterdrücken

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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Verordnung der Chromatin-Umgebung ist ein wesentlicher Prozess erforderlich für die ordnungsgemäße Genexpression. Hier beschreiben wir eine Methode zur Steuerung der Genexpression durch die Rekrutierung von Chromatin-modifizierende Maschinen Gen-spezifischen und reversibel.

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Ausgabe 139 chemische Biologie Bioengineering bifunktionelle Moleküle chemisch induzierte Chromatin Verordnung gen Unterdrückung Histon Deacetylase Epigenetik Nähe chemische epigenetische Modifikatoren CEMs
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