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Den CYP2D6 Animal Model
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Den CYP2D6 Animal Model: Sådan Fremkald autoimmun hepatitis i mus

Article DOI: 10.3791/3644-v • 09:03 min • February 3rd, 2012
February 3rd, 2012 •
1, 1, 1
1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

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Infektion af mus med en Adenovirus udtrykker den vigtigste humane autoantigenet cytochrom P450 2D6 (hCYP2D6) anerkendt af sera af patienter, der lider type 2 autoimmun hepatitis resultater i en vedvarende form af autoimmun-medieret leversygdom kendetegnet af omfattende hepatitis, fibrose og generering af en CYP2D6 -specifikt immunrespons.

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Medicin autoimmunitet lever autoantigen fibrose perfusion
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