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Immunology and Infection
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一个<em>在体外</em>共感染模型研究<em>恶性疟原虫</em人原发性单核细胞源性的免疫细胞-HIV-1相互作用
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
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一个<em>在体外</em>共感染模型研究<em>恶性疟原虫</em人原发性单核细胞源性的免疫细胞-HIV-1相互作用

DOI:
10.3791/4166-v

•

07:39 min

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August 15, 2012

•

, , , ,
1Infectious Disease Research Center,CHUL (CHUQ), Quebec City, Quebec, Canada

Chapters

  • 00:05Title
  • 01:45Plasmodium falciparum-infected Red Blood Cell (iRBC) Purification
  • 02:35Exposure of Monocyte-derived Macrophages (MDM) to Plasmodium falciparum
  • 03:40Infection of MDM with a Fully Replicative HIV-1
  • 04:44Infection of MDM with Single Cycle Virus Encoding Luciferase
  • 05:56Results: Exposure of P. falciparum to MDM Decreases their Susceptibility to HIV-1 Infection
  • 07:16Conclusion

Summary

Automatic Translation

Automatic Translation

我们已经制定了一个<em>在体外</em>疟疾，HIV-1病毒共感染模型研究的影响<em>恶性疟原虫</em>在人类原发性单核细胞源性巨噬细胞的HIV-1病毒复制周期。这种多用途的系统可以很容易地适应其他主要易感HIV-1感染的细胞类型。

Tags

In Vitro Co-infection ModelPlasmodium FalciparumHIV-1 InteractionsHuman Primary Monocyte-derived Immune CellsMalariaHIV-1Co-infectionsDisease ProgressionTransmissionImmunological MechanismsSoluble Malarial AntigensHIV-1 InfectionReactivationImmune CellsP. Falciparum Schizont Stage ParasitesPeripheral Blood Mononuclear Cells

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