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Chapters
- 00:05Title
- 01:25MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Preparation
- 03:50MPTP Administration
- 05:59Results: 5-LOX and 12/15-LOX Differentially Impact the Nigrostriatal Dopaminergic Vulnerability
- 07:40Conclusion
Lipoxygenase (LOX) isozymer kan generere produkter, der kan øge eller mindske neuroinflammation og neurodegeneration. En interaktionsundersøgelse mellem gen og miljø kunne identificere LOX isozymspecifikke virkninger. Ved hjælp af 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) model af nigrostriatal skader i to LOX isozym-mangelfulde transgene linjer giver mulighed for sammenligning af bidraget fra LOX isozymer på dopaminergisk integritet og inflammation.
