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Gene-miljø Interaktion Modeller til unmask modtagelighed mekanismer i Parkinsons sygdom
JoVE Journal
Medicine
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JoVE Journal Medicine
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
DOI:

08:09 min

January 07, 2014

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Chapters

  • 00:05Title
  • 01:25MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Preparation
  • 03:50MPTP Administration
  • 05:59Results: 5-LOX and 12/15-LOX Differentially Impact the Nigrostriatal Dopaminergic Vulnerability
  • 07:40Conclusion

Summary

Automatic Translation

Lipoxygenase (LOX) isozymer kan generere produkter, der kan øge eller mindske neuroinflammation og neurodegeneration. En interaktionsundersøgelse mellem gen og miljø kunne identificere LOX isozymspecifikke virkninger. Ved hjælp af 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) model af nigrostriatal skader i to LOX isozym-mangelfulde transgene linjer giver mulighed for sammenligning af bidraget fra LOX isozymer på dopaminergisk integritet og inflammation.

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