Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Varahram Shahryari; Hannah Nip; Sharanjot Saini; Altaf A. Dar; Soichiro Yamamura; Yozo Mitsui; Melissa Colden; Nathan Bucay; Laura Z. Tabatabai; Kirsten Greene; Guoren Deng; Yuichiro Tanaka; Rajvir Dahiya; Shahana Majid

doi:10.3791/54125

Journal

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Medicine

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İnsan Prostat Kanseri klinik öncesi Ortotopik murin modeli

JoVE Journal
Medicine

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JoVE Journal Medicine

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

İnsan Prostat Kanseri klinik öncesi Ortotopik murin modeli

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14,117 Views

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07:01 min

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August 29, 2016

DOI:

10.3791/54125-v

DOI:

10.3791/54125-v

•

07:01 min

August 29, 2016

•

12 Views

Varahram Shahryari¹, Hannah Nip¹, Sharanjot Saini¹, Altaf A. Dar², Soichiro Yamamura¹, Yozo Mitsui¹, Melissa Colden¹, Nathan Bucay¹, Laura Z. Tabatabai¹, Kirsten Greene¹, Guoren Deng¹, Yuichiro Tanaka¹, Rajvir Dahiya¹, Shahana Majid¹

¹Department of Urology,VA Medical Center and UCSF, ²California Pacific Medical Center Research Institute

Transcript

Summary

Prostate cancer is the second most common cause of cancer-related deaths in the United States. An orthotopic cancer model provides a useful approach to understand the biology of prostate cancer and to evaluate the efficacy of therapeutic regimens. This protocol describes detailed steps necessary to establish an orthotopic prostate cancer mouse model.