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Chapters
- 00:05Title
- 01:55Tumor Cell Implantation
- 05:14Results: In Vivo Intra-prostatic Implantation Bioluminescence Imaging
- 05:54Conclusion
Prostate cancer is the second most common cause of cancer-related deaths in the United States. An orthotopic cancer model provides a useful approach to understand the biology of prostate cancer and to evaluate the efficacy of therapeutic regimens. This protocol describes detailed steps necessary to establish an orthotopic prostate cancer mouse model.
Tags
Keywords:
OrthotopicMurineProstate CancerXenograft ModelMetastatic CascadePrimary Tumor DevelopmentPre-clinical EvaluationTherapeutic ApproachesMetastasisMolecular MechanismsTrypan Blue ExclusionBasement Membrane-like Extracellular MatrixImmunocompromised Male MiceSurgical ProcedurePovidone IodineEthanol
