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Journal
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Bioengineering
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一种三肽稳定的油酸纳米乳液
JoVE Journal
Bioengineering
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JoVE Journal
Bioengineering
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Please note that all translations are automatically generated.
Click here for the English version.
一种三肽稳定的油酸纳米乳液
DOI:
10.3791/59034-v
•
10:42 min
•
February 27, 2019
•
Sylwia A. Dragulska
,
Marek T. Wlodarczyk
2
,
Mina Poursharifi
3
,
John A. Martignetti
5,6
,
Aneta J. Mieszawska
2,3
1
Department of Chemistry
,
Brooklyn College, The City University of New York
,
2
Ph.D. Program in Chemistry
,
The Graduate Center of The City University of New York
,
3
Ph.D. Program in Biochemistry
,
The Graduate Center of The City University of New York
,
4
Department of Genetics and Genomic Sciences
,
Icahn School of Medicine at Mount Sinai
,
5
Women’s Health Research Institute
,
Icahn School of Medicine at Mount Sinai
,
6
Laboratory for Translational Research
,
Western Connecticut Health Network
Chapters
00:04
Title
00:35
Synthesis of Oleic Acid-Platinum(II) Conjugate
02:41
Preparation of Unmodified and Fluorescein Isothiocyanate (FITC)-Modified Lysine-Tyrosine-Phenylalanine (KYF) Tripeptide
05:59
Synthesis of FITC-KYF-Stabilized or KYF-Stabilized Nanoemulsion with Oleic Acid-Pt(II) Cores (FITC-KYF-Pt-NE or KYF-Pt-NE)
08:03
Results: KYF-Pt-NE and FITC-KYF-Pt-NE Characterization
09:43
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
该方案描述了一种合成与赖氨酸-酪氨酸-苯基丙氨酸 (kyf) 三肽稳定的油酸-铂 (ii) 共轭纳米乳液的有效方法。纳米乳液通过 kyf 和共轭的自组装在温和的合成条件下形成。
Tags
Tripeptide
Nanoemulsion
Oleic Acid
Cisplatin
Platinum
Ovarian Cancer
Peptide Modification
Diagnostic
Pharmaceutical
In-vivo Studies
Fmoc
L-phenylalanine
L-tyrosine
TBTU
DIPEA
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