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Journal / Cancer Research / Intramucosal vaksinasjon av Squamous celle…
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JoVE Journal Cancer Research
Intramucosal vaksinasjon av Squamous celle Carcinoma celler i mus for svulst immun profilering og behandling respons vurdering
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Intramucosal vaksinasjon av Squamous celle Carcinoma celler i mus for svulst immun profilering og behandling respons vurdering

Article DOI: 10.3791/59195-v • 07:29 min • April 22nd, 2019
April 22nd, 2019 •
1, 1, 1, 1, 1,2,3, 1
1Department of Radiation Oncology, University of Colorado Denver - Anschutz Medical Campus, 2Department of Anesthesiology, University of Colorado Denver - Anschutz Medical Campus, 3Division of Radiology, University of Colorado Denver - Anschutz Medical Campus

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Her presenterer vi en reproduserbar metode for å utvikle en orthotopic murint modell av hodet og nakken squamous celle carcinoma. Svulster viser klinisk relevante histopathological funksjoner av sykdommen, inkludert nekrose, dårlig differensiering, knutepunktet metastaser og immun infiltrasjon. Svulst-bærende mus utvikle klinisk relevante symptomer inkludert dysfagi, kjeven forskyvning og vekttap.

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Kreftforskning problemet 146 hode og nakke kreft orthotopic modell svulst microenvironment immun evasion flowcytometri masse cytometri
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