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Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Article DOI: 10.3791/59754
December 5th, 2019


Summary December 5th, 2019

Described here is a protocol for direct immunolabelling of necrotic myofibers in muscle cryosections. Necrotic cells are permeable to serum proteins, including immunoglobulin G (IgG). Revealing the uptake of IgG by myofibers allows the identification and quantification of myofibers that undergo necrosis regardless of muscle condition.


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