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Methylnitrosourea (MNU)-induced Retinal Degeneration and Regeneration in the Zebrafish

Methylnitrosourea (MNU)-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

Article DOI: 10.3791/51909-v 08:53 min October 20th, 2014
October 20th, 2014



Herein we demonstrate quantification of retinal de- and regeneration and its impact on visual function using N-methyl-N-nitrosourea in the adult zebrafish. Loss of visual acuity and decreased photoreceptor numbers were followed by proliferation in the inner nuclear layer. Complete morphological and functional regeneration occurred 30 days after the initial treatment.


Methylnitrosourea MNU-induced Retinal Degeneration Retinitis Pigmentosa Photoreceptor Damage Animal Models Zebrafish Neurogenesis Regeneration Visual Acuity Measurements Optokinetic Reflex Apoptosis Proliferation Histology
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