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Murine kirurgisk model af aktuel elastase induceret faldende Thoracic aorta aneurisme
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JoVE Journal Medicine
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine kirurgisk model af aktuel elastase induceret faldende Thoracic aorta aneurisme

DOI:
10.3791/60105-v

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00:08 min

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August 24, 2019

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, , , , , , , ,
1Department of Surgery,University of Virginia School of Medicine, 2Department of Surgery,Ochsner Medical Center, 3Department of Surgery,University of Florida, 4The Robert M. Berne Cardiovascular Research Center,University of Virginia School of Medicine

Chapters

  • 00:04Title
  • 00:33Mouse Position Preparation
  • 01:09Thorax Entry
  • 02:24Aortic Exposure
  • 03:04Elastase Exposure
  • 03:48Chest Closure and Recovery
  • 04:28Thoracic Aortic Aneurysm (TAA) Harvest
  • 06:58Results: Representative Effects of TAA Formation
  • 07:54Conclusion

Summary

Automatic Translation

Automatic Translation

Vi beskriver en kirurgisk protokol til konsekvent at inducere robust nedadgående thorax aorta aneurismer i mus. Proceduren involverer venstre thoracotomi, thorax aorta eksponering, og placering af en svamp gennemblødt i Porcin pancreas elastase på aorta væggen.

Tags

Murine Surgical ModelTopical ElastaseDescending Thoracic Aortic AneurysmC57 Black Six MouseThoracotomyAortic DissectionPorcine Pancreatic Elastase

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