Journal
/
Medicine
/
通过结合70%部分切除术和对乙酰氨基酚，生成急性肝衰竭大鼠模型
JoVE Journal
Medicine
Author Produced
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Please note that all translations are automatically generated. Click here for the English version.

通过结合70%部分切除术和对乙酰氨基酚，生成急性肝衰竭大鼠模型

DOI:
10.3791/60146-v

•

09:44 min

•

November 27, 2019

•

, , , , , , , , , ,
1National Institute of Immunology, 2Center for Cellular and Molecular Biology

Chapters

  • 00:00Title
  • 01:54Procedure
  • 02:13Pre-operative Procedures
  • 03:12Partial Hepatectomy to Remove 70% Liver Mass
  • 05:38Post-operative Care
  • 06:35Injection of Drug in Partially Hepatectomized Animals to induce Liver Failure
  • 06:58Results
  • 09:19Conclusion

Summary

Automatic Translation

Automatic Translation

本研究开发的急性肝衰竭动物模型为研究潜在疗法提供了可行的替代方法。目前的模型采用身体和药物引起的肝损伤的综合效应，为研究新疗法的潜力提供了一个合适的时间窗口。

Tags

Acute Liver FailureRat ModelPartial HepatectomyAcetaminophenHepatotoxicityLiver TransplantLiver MassBiochemical AnalysisHistological AnalysisSyngeneic Hepatocyte TransplantationAnesthesiaSurgical ProcedureLiver Damage Reversibility

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

部分原位肝移植大鼠模型的肝动脉重建的外科手术

在急性肝衰竭异位辅助性大鼠肝移植流量调节门静脉动脉

之后，正常小鼠70％部分肝切除血管和实质再生的可视化

直接节段性肝内交付使用大鼠肝门部夹具模型方法

肝分型与门静脉结扎大鼠分期肝切除 (ALPPS) 手术模型的建立

肝细胞部分肝切除术后脾移植。小鼠

静脉大鼠部分肝移植的体内血管定向70% 肝切除术

脂肪组织干细胞移植对大鼠部分结肠切除术后渗漏的减少

代谢综合征心力衰竭模型大鼠心房心肌细胞的分离与保留射血分数的关系

慢性血栓栓塞性肺动脉高压大型动物模型中急性右心衰竭的诱导和表型分析

Read Article