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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
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JoVE Journal Behavior
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

DOI:
10.3791/60751-v

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13:34 min

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June 04, 2020

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, , ,
1Department of Pharmacology, Department of Biomedicine & Health Sciences, Catholic Neuroscience Institute, Institute of Aging and Metabolic Diseases, College of Medicine,The Catholic University of Korea

Chapters

  • 00:04Introduction
  • 00:44Novel Object Location Test (NL)
  • 05:34Novel Object Recognition Test (NO)
  • 08:18Pattern Separation Test (PS)
  • 11:13Results: Behavioral Apparatus, Spatial Memory, and Neuronal Death
  • 12:32Conclusion

Summary

Automatic Translation

Automatic Translation

This article presents experimental procedures for assessing memory impairments in pilocarpine-induced epileptic mice. This protocol can be used to study the pathophysiologic mechanisms of epilepsy-associated cognitive decline, which is one of the most common comorbidities in epilepsy.

Tags

Keywords: Memory FunctionPilocarpine-induced EpilepsyMouse ModelNovel Object LocationNovel Object RecognitionPattern Separation TestLocomotor ActivityOpen Field BoxVideo Tracking SoftwareIlluminance

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