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JoVE Journal
Developmental Biology

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Generation of a Human iPSC-Based Blood-Brain Barrier Chip
 

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Article DOI: 10.3791/60925-v
March 2nd, 2020

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Summary March 2nd, 2020

The blood-brain barrier (BBB) is a multicellular neurovascular unit tightly regulating brain homeostasis. By combining human iPSCs and organ-on-chip technologies, we have generated a personalized BBB chip, suitable for disease modeling and CNS drug penetrability predictions. A detailed protocol is described for the generation and operation of the BBB chip.

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