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JoVE Journal Chemistry
Rettet montering av elastinlignende proteiner i definerte supramolekylære strukturer og lastinnkapsling in vitro
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Rettet montering av elastinlignende proteiner i definerte supramolekylære strukturer og lastinnkapsling in vitro

Article DOI: 10.3791/60935-v • 10:01 min • April 8th, 2020
April 8th, 2020 •
*1,2, *1,2, 1,2, 1,2, 1,2,3,4,5,6
1Center for Biological Systems Analysis, University of Freiburg, 2Faculty of Biology, University of Freiburg, 3Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, 4BIOSS Centre for Biological Signalling Studies, University of Freiburg, 5IMTEK Department of Microsystems Engineering, University of Freiburg, 6Cluster of Excellence livMatS at FIT - Freiburg Center for Interactive Materials and Bioinspired Technologies, University of Freiburg
* These authors contributed equally

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Ved grensesnittet av organiske og vandige løsemidler samles skreddersydde amfifile elastinlignende proteiner i komplekse supramolekylære strukturer som vesikler, fibre og koacervater utløst av miljøparametere. De beskrevne monteringsprotokollene gir proteinmembranbaserte rom (PMBC-er) med justerbare egenskaper, noe som muliggjør innkapsling av ulike laster.

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Kjemi Utgave 158 elastinlignende proteiner proteinbaserte vesikler proteinfibre legemiddelleveringssystemer selvmontering proteinmembran
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