Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

9.3K views

Cited by 4

07:13 min

October 20th, 2021

10.3791/63085-v

October 20th, 2021

9.3K views

Hongkai Wang¹^,² , Dom D’Andrea¹ , Yeon Sik Choi³^,⁴ , Yasmine Bouricha¹ , Grace Wickerson³^,⁴ , Hak-Young Ahn³ , Hexia Guo³^,⁴ , Yonggang Huang³^,⁴^,⁵^,⁶ , Milap S. Sandhu⁷ , Sumanas W. Jordan⁸ , John A. Rogers³^,⁴^,⁶^,⁹^,¹⁰^,¹¹^,¹² , Colin K. Franz¹^,³^,¹³

¹Laboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ²Northwestern University Interdepartmental Neuroscience Program, ³Center for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University, ⁴Department of Materials Science and Engineering, Northwestern University, ⁵Department of Civil and Environmental Engineering, Northwestern University, ⁶Department of Mechanical Engineering, Northwestern University, ⁷Arms and Hands Lab, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ⁸Division of Plastic and Reconstructive Surgery, Biologics, Shirley Ryan AbilityLab, Northwestern University, ⁹Department of Biomedical Engineering, Northwestern University, ¹⁰Department of Neurological Surgery, Northwestern University, ¹¹Department of Chemistry, Northwestern University, ¹²Department of Electrical and Computer Engineering, Northwestern University, ¹³The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine

This is a protocol for the surgical implantation and operation of a wirelessly powered interface for peripheral nerves. We demonstrate the utility of this approach with examples from nerve stimulators placed on either the rat sciatic or phrenic nerve.

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Chapters in this video

0:00

Introduction

0:58

Surgical Procedure for Implantation of a Wireless, Battery‐Free Peripheral Nerve Interface on the Right Sciatic Nerve of the Rat for Electrical Stimulation

3:07

Surgical Procedure for the Implantation of Wireless Stimulators on the Left Phrenic Nerve of the Rat

4:46

Wireless Delivery of Therapeutic Electrical Stimulation

5:29

Results: Nerve Conduction Studies, EMG Recording, and Nerve Regeneration in the Sciatic Nerve Injury Model

6:42

Conclusion

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