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Journal / Biochemistry / 细胞性谷胱甘肽S-转移酶潜在抑制剂的分光光度筛选…
JoVE Journal
Biochemistry
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JoVE Journal Biochemistry
细胞性谷胱甘肽S-转移酶潜在抑制剂的分光光度筛选
Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
Journal (Biochemistry)
Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography
Journal (Biochemistry)
Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography
 
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细胞性谷胱甘肽S-转移酶潜在抑制剂的分光光度筛选

Article DOI: 10.3791/61347-v • 14:57 min • October 10th, 2020
October 10th, 2020 •
1,2, *1,3, *1,3
1Research platform of Pediatric Onco-Hematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, 2Section of Biology, Faculty of Science, University of Geneva, 3Onco-Hematology Unit, Department of Women, Children-Adolescents, University Hospitals of Geneva
* These authors contributed equally

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Summary
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谷胱甘肽S-转移酶（GSTs）是参与许多化疗药物代谢的解毒酶。GSTs的表达与癌症化疗的抗性相关。对抗这种表型的一个方法就是使用抑制剂。该协议描述了一种使用分光光度测定来筛选潜在GST抑制剂的方法。

Tags

生物化学， 问题 164， 谷胱甘肽 S- 转移酶， GST 抑制剂， 酶测定， 抑制分析， IC50， Ki
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