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Journal / Biochemistry / Spektrofotometrisk screening for potentielle…
JoVE Journal
Biochemistry
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JoVE Journal Biochemistry
Spektrofotometrisk screening for potentielle hæmmere af cytosol glutathion S-transferaser
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Journal (Biochemistry)
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
Journal (Biochemistry)
Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
 
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Spektrofotometrisk screening for potentielle hæmmere af cytosol glutathion S-transferaser

Article DOI: 10.3791/61347-v • 14:57 min • October 10th, 2020
October 10th, 2020 •
1,2, *1,3, *1,3
1Research platform of Pediatric Onco-Hematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, 2Section of Biology, Faculty of Science, University of Geneva, 3Onco-Hematology Unit, Department of Women, Children-Adolescents, University Hospitals of Geneva
* These authors contributed equally

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Glutathion S-transferaser (GSTs) er afgiftning enzymer involveret i metabolismen af talrige kemoterapeutiske lægemidler. Overekspression af GST'er er korreleret med kræft kemoterapi resistens. En måde at imødegå denne fænotype er at bruge hæmmere. Denne protokol beskriver en metode, der anvender en spektrofotometrisk analyse til skærmen for potentielle GST-hæmmere.

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Biokemi Glutathion S-transferaser GST-hæmmere enzymanalyse hæmningsanalyse IC50 Ki
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