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Journal / Biochemistry / Sitosolion Glutatyon S-Transferazlarının…
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Biochemistry
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JoVE Journal Biochemistry
Sitosolion Glutatyon S-Transferazlarının Potansiyel Inhibitörleri için Spektrofotometrik Tarama
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Sitosolion Glutatyon S-Transferazlarının Potansiyel Inhibitörleri için Spektrofotometrik Tarama

Article DOI: 10.3791/61347-v • 14:57 min • October 10th, 2020
October 10th, 2020 •
1,2, *1,3, *1,3
1Research platform of Pediatric Onco-Hematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, 2Section of Biology, Faculty of Science, University of Geneva, 3Onco-Hematology Unit, Department of Women, Children-Adolescents, University Hospitals of Geneva
* These authors contributed equally

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Glutatyon S-transferazlar (GSTs) çok sayıda kemoterapötik ilaçların metabolizmasında rol oynayan detoksifikasyon enzimleridir. GST'lerin aşırı ekspresyonu kanser kemoterapi direnci ile ilişkilidir. Bu fenotip karşı bir yolu inhibitörleri kullanmaktır. Bu protokol, potansiyel GST inhibitörlerini taramak için spektrofotometrik bir test kullanarak bir yöntem tanımlar.

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Biyokimya Sayı 164 Glutatyon S-transferazları GST inhibitörleri enzim testleri inhibisyon tayı IC50 Ki
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