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Bioengineering

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JoVE Journal Bioengineering
Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Article DOI: 10.3791/61545-v • 08:13 min • December 3rd, 2020
December 3rd, 2020 •
1, 1, 1,2, 1,2, *1,2, *1,2
1The Children's Hospital of Philadelphia, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania
* These authors contributed equally

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Hier wird ein Protokoll zum Anhängen von Peptid CD47 (pepCD47) an Metallstents mit Polybisphosphonatchemie vorgestellt. Die Funktionalisierung von Metallstents mit pepCD47 verhindert die Anhaftung und Aktivierung von Entzündungszellen und verbessert so deren Biokompatibilität.

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Bioengineering Ausgabe 166 Oberflächenfunktionalisierung Metall Implantate Stents CD47 Entzündung Thrombose Peptide Biokonjugation
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