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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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07:46 min

April 30, 2021

DOI:

07:46 min
April 30, 2021

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Summary

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In the age of immunotherapy and single-cell genomic profiling, cancer biology requires novel in vitro and computational tools for investigating the tumor-immune interface in a proper spatiotemporal context. We describe protocols to exploit tumor-immune microfluidic co-cultures in 2D and 3D settings, compatible with dynamic, multiparametric monitoring of cellular functions.

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