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Biochemistry

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Workflow and Tools for Crystallographic Fragment Screening på Helmholtz-Zentrum Berlin
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Workflow and Tools for Crystallographic Fragment Screening på Helmholtz-Zentrum Berlin

Article DOI: 10.3791/62208-v • 06:29 min • March 3rd, 2021
March 3rd, 2021 •
1, 1,2, 3, 4, 5, 3, 1,4, 1, 1, 1, 1, 1, 1, 4, 4, 1, 1
1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin

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Krystallografisk fragmentscreening på Helmholtz-Zentrum Berlin udføres ved hjælp af en arbejdsgang med dedikerede sammensatte biblioteker, krystalhåndteringsværktøjer, hurtige dataindsamlingsfaciliteter og stort set automatiseret dataanalyse. Den fremlagte protokol har til formål at maksimere produktionen af sådanne eksperimenter for at give lovende udgangspunkter for downstream strukturbaseret ligand design.

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Biokemi krystallografisk fragment screening sammensatte bibliotek krystal håndtering ligand iblødsætning FBDD makromolekylær krystallografi databehandling hit identifikation
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