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通过在小鼠心脏中应用光遗传学多位点光刺激进行高级心律管理
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JoVE Journal
Medicine
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
Please note that all translations are automatically generated.
Click here for the English version.
通过在小鼠心脏中应用光遗传学多位点光刺激进行高级心律管理
DOI:
10.3791/62335-v
•
08:43 min
•
August 26, 2021
•
Laura Diaz-Maue*
1,2
,
Janna Steinebach*
1
,
Michael Schwaerzle
9
,
Stefan Luther
3,4,6
,
Patrick Ruther
9
,
Claudia Richter
5,6,7
1
Research Group Biomedical Physics
,
Max Planck Institute for Dynamics and Self-Organization
,
2
Research Electronics Department
,
Max Planck Institute for Dynamics and Self-Organization
,
3
Department of Pharmacology and Toxicology
,
University Medical Center Goettingen
,
4
Institute for Nonlinear Dynamics
,
Georg-August-University Goettingen
,
5
Department of Cardiology and Pneumology
,
University Medical Center Goettingen
,
6
German Center for Cardiovascular Research
,
DZHK e.V., partner site Goettingen
,
7
Laboratory Animal Science Unit
,
German Primate Center Leibniz Institute for Primate Research
,
8
Department of Microsystems Engineering (IMTEK)
,
University of Freiburg
,
9
Cluster of Excellence BrainLinks-BrainTools
,
University of Freiburg
Chapters
00:04
Introduction
00:54
Langendorff Perfusion
02:53
Arrhythmia Induction and Optical Defibrillation
04:41
Optical Mapping
05:45
Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation
07:56
Conclusion
Summary
Automatic Translation
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Automatic Translation
这项工作报告了一种使用micro-LED阵列的局部光刺激和同时光学映射心外膜电位来控制转基因通道视紫红质-2(ChR2)小鼠完整鼠心脏心律的方法。
Tags
Optogenetics
Cardiac Rhythm Management
Multi-site Photostimulation
Murine Hearts
Cardiac Fibrillation
Defibrillation
Micro LED Array
ECG
Thyroid Solution
Perfusion System
Cardiac Arrhythmia
Large Animal Models
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