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標的ナノ粒子の研究のための乳癌の同質性マウスモデルからの原発癌関連線維芽細胞の分離
JoVE Journal
Cancer Research
This content is Free Access.
JoVE Journal Cancer Research
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
DOI:

08:02 min

May 14, 2021

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Chapters

  • 00:04Introduction
  • 00:37Tumor Dissociation into Single Cells
  • 02:55Extraction of Cancer-Associated Fibroblasts (CAFs) from Dissociated Tumor
  • 05:20Results-I: Isolation and Culture of Primary CAFs from a Syngeneic Murine Breast Cancer
  • 06:40Results-II: Use of Isolated CAFs to Evaluate Targeting Potential of Hfn-FAP Functionalized Nanodrugs
  • 07:08Conclusion

Summary

Automatic Translation

本論文は、三重陰性乳癌の同種マウスモデルからの原発性癌関連線維芽細胞の単離と培養と、腫瘍微小環境を標的とするように設計された新規ナノ粒子の前臨床試験への応用を目的とする。

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