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帕金森病的6-羟基多巴胺大鼠模型
JoVE Journal
Neuroscience
Author Produced
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JoVE Journal Neuroscience
The 6-hydroxydopamine Rat Model of Parkinson’s Disease
DOI:

08:10 min

October 27, 2021

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Chapters

  • 00:04Introduction
  • 01:00Training for Stepping and Test
  • 03:18Surgical Procedure
  • 06:06Results: Results of Stepping Test and Histological Analysis
  • 07:30Conclusion

Summary

Automatic Translation

6-羟基多巴胺(6-OHDA)模型已经使用了几十年,以推进对帕金森病的理解。在该协议中,我们展示了如何通过在内侧前脑束中注射6-OHDA来执行大鼠的单侧黑质纹状体病变,评估运动缺陷并使用步进测试预测病变。

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