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Den 6-hydroxydopamin rotte model af Parkinsons sygdom
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Den 6-hydroxydopamin rotte model af Parkinsons sygdom

Article DOI: 10.3791/62923-v • 08:10 min • October 27th, 2021
October 27th, 2021 •
1, 1, 1, 1, 1, 1
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo

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6-hydroxydopamin (6-OHDA) modellen er blevet brugt i årtier til at fremme forståelsen af Parkinsons sygdom. I denne protokol demonstrerer vi, hvordan man udfører ensidige nigrostriatale læsioner hos rotten ved at injicere 6-OHDA i det mediale forhjernebundt, vurdere motoriske underskud og forudsige læsioner ved hjælp af trintesten.

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Neurovidenskab udgave 176
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