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心臓同種移植への治療薬の送達のためのブタヘテロトピック心臓移植プロトコル
JoVE Journal
Medicine
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JoVE Journal
Medicine
A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Please note that all translations are automatically generated.
Click here for the English version.
心臓同種移植への治療薬の送達のためのブタヘテロトピック心臓移植プロトコル
DOI:
10.3791/63114-v
•
08:30 min
•
February 14, 2022
•
Michelle Mendiola Pla
,
Amy Evans
,
Franklin H. Lee
,
Yuting Chiang
,
Muath Bishawi
,
Andrew Vekstein
,
Lillian Kang
,
Diego Zapata
,
Ryan Gross
,
Alexis Carnes
,
Lynden E. Gault
,
Julie A. Balko
,
Desiree Bonadonna
,
Sam Ho
,
Paul Lezberg
,
Benjamin S. Bryner
,
Jacob N. Schroder
,
Carmelo A. Milano
,
Dawn E. Bowles
1
Division of Cardiothoracic Surgery, Department of Surgery
,
Duke University
,
2
Perfusion Services
,
Duke University
,
3
Division of Surgical Sciences, Department of Surgery
,
Duke University
,
4
Division of Laboratory Animal Resources
,
Duke University
,
5
Gift of Hope Organ and Tissue Donor Network
,
6
College of Veterinary Medicine
,
North Carolina State University
,
7
TransMedics, Inc
Chapters
00:04
Introduction
01:00
Median Sternotomy of the Donor Pig
01:56
Cardiac Arrest and Cardiectomy of the Donor Pig
03:39
Back-Table Preparation of the Donor Heart and Reanimating the Heart
04:47
Preparation of the Recipient and Laparotomy with Vascular Exposure
05:45
Heterotopic Implantation of the Cardiac Graft and Closure of the Laparotomy
06:49
Results: Analysis of Perfusion Parameters and Transplanted Heart
07:36
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
我々は、ブタ異所性心臓移植モデルにおける心臓同種移植片全体への治療薬の送達のために、正常温熱
エクスビボ
正気灌流システムを利用するためのプロトコルを提示する。
Tags
Porcine
Heterotopic
Heart Transplantation
Cardiac Allograft
Therapeutics
Perfusion
Sternotomy
Aortic Cross Clamp
Cardioplegia
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