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JoVE Journal Neuroscience
Valutazione locomotoria del modello di malattia di Parkinson a base di zebrafish adulto indotto da 6-idrossidopamina
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Valutazione locomotoria del modello di malattia di Parkinson a base di zebrafish adulto indotto da 6-idrossidopamina

Article DOI: 10.3791/63355-v • 07:32 min • December 28th, 2021
December 28th, 2021 •
1, 1, 1,2, 1, 1, 2, 1
1Collaborative Drug Discovery Research (CDDR) Group and Brain Degeneration and Therapeutics Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, 2Department of Medicine, Faculty of Medicine, Universiti Malaya

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Il presente protocollo descrive l'iniezione intracerebroventricolare (ICV) di zebrafish adulto con 6-idrossidopamina neurotossica (6-OHDA) al diencefalo ventrale (Dn) e la valutazione della compromissione e del successivo recupero del comportamento di nuoto postlesione utilizzando il test in vasca aperta, che è accompagnato da analisi utilizzando un software di tracciamento video.

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Neuroscienze Numero 178
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