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大鼠主动脉切除术治疗左心病肺动脉高压反向血管重塑模型
JoVE Journal
Medicine
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JoVE Journal
Medicine
A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Please note that all translations are automatically generated.
Click here for the English version.
大鼠主动脉切除术治疗左心病肺动脉高压反向血管重塑模型
DOI:
10.3791/63502-v
•
07:41 min
•
March 01, 2022
•
Pengchao Sang
2,3
,
Mariya M. Kucherenko
2,3
,
Juquan Yao
,
Qiuhua Li
,
Szandor Simmons
3
,
Wolfgang M. Kuebler*
2,3
,
Christoph Knosalla*
1,3,4
1
Department of Cardiothoracic and Vascular Surgery
,
German Heart Center Berlin (DHZB)
,
2
Institute of Physiology
,
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
,
3
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin
,
4
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Chapters
00:05
Introduction
00:42
Surgical Preparations and Tracheotomy and Mechanical Ventilation
02:24
Aortic Debanding
04:06
Tracheal Extubation and Post-Operative Care
05:19
Results: Analysis of Aortic Blood Flow, Ventricular Function, and Hemodynamics after Debanding Surgery
07:09
Conclusion
Summary
Automatic Translation
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Automatic Translation
本方案描述了一种外科手术,用于去除左心病引起的肺动脉高压大鼠模型中的升主动脉束带。该技术研究肺循环和右心中反向重塑的内源性机制,从而为逆转肺动脉高压和/或右心室功能不全的策略提供信息。
Tags
Aortic Debanding
Pulmonary Hypertension
Reverse Vascular Remodeling
Left Heart Disease
Rat Model
Reverse Remodeling
Surgical Procedure
Tracheotomy
Mechanical Ventilation
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