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JoVE Journal Cancer Research
Digital rumlig profilering til karakterisering af mikromiljøet i voksentype diffust infiltrerende gliom
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Digital rumlig profilering til karakterisering af mikromiljøet i voksentype diffust infiltrerende gliom

Article DOI: 10.3791/63620-v • 09:17 min • September 13th, 2022
September 13th, 2022 •
1, 2, 2, 3, 2, 2,4
1Department of Neurology, Dartmouth-Hitchcock Medical Center, 2Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 3Department of Neurosurgery, Dartmouth-Hitchcock Medical Center, 4Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center

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Proteomisk dysregulering spiller en vigtig rolle i spredningen af diffust infiltrerende gliomer, men flere relevante proteiner forbliver uidentificerede. Digital rumlig behandling (DSP) tilbyder en effektiv tilgang med høj kapacitet til karakterisering af differentiel ekspression af kandidatproteiner, der kan bidrage til invasion og migration af infiltrative gliomer.

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