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Modelo de quemadura de rata para estudiar la quemadura térmica cutánea de espesor total y la infección
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1UNC Eshelman School of Pharmacy,University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences,The University of Melbourne, 3Department of Microbiology & Immunology,University of North Carolina School of Medicine, 4Department of Surgery,University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine,University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute,Monash University
Chapters
- 00:05Introduction
- 00:57Preparing Rats for the Burn Injury
- 01:54Inducing the Burn Injury in Rats
- 03:20Preparation of Bacterial Inoculum and Infection
- 04:26Evaluation of the Burn Injury and Postprocessing of Rat Samples and Bacterial Enumeration
- 05:37Results: A Simple and Reproducible Rat Burn Infection Model
- 07:59Conclusion
Un modelo que imite el escenario clínico de lesiones por quemaduras e infecciones es necesario para avanzar en la investigación de quemaduras. El presente protocolo demuestra un modelo simple y reproducible de infección por quemaduras de rata comparable al de los seres humanos. Esto facilita el estudio de quemaduras e infecciones después de quemaduras para desarrollar nuevos tratamientos antibióticos tópicos.
