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Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
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Neuroscience
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JoVE Journal Neuroscience
Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

DOI:
10.3791/64567-v

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04:20 min

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November 11, 2022

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, , ,
1Titus Family Department of Clinical Pharmacy, School of Pharmacy,University of Southern California, 2Homer Stryker M.D. School of Medicine,Western Michigan University

Chapters

  • 00:05Introduction
  • 00:36Animals and Cage Setup
  • 01:34Care and Treatment During the Social Isolation Period
  • 01:58Agar Drug/Treatment Preparation: A Non-Invasive Drug Treatment and Behavioral Analysis
  • 03:15Results: Social Isolation (SI)-Induced Anxiety Mouse Model
  • 03:56Conclusion

Summary

Automatic Translation

Automatic Translation

Presented here is a social isolation (SI)-induced anxiety mouse model that utilizes wild type C56BL/6J mice to induce stress and anxiety-like behavior with minimal handling and no invasive procedures. This model reflects modern life patterns of social isolation and is ideal for studying anxiety and related disorders.

Tags

Keywords: Social IsolationRodent ModelStressAnxietyNoninvasiveCognitive ImpairmentHousing ConditionsTreatmentAgarSucroseLight-sensitiveHandling

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